Projects & Publications

Patel, R. S*., Tomlinson, J. E*., Divers, T. J., Van de Walle, G. R., & Rosenberg, B. R. (2020). Single cell resolution landscape of equine peripheral blood mononuclear cells reveals diverse cell types including T-bet+ B cells. BMC Biology. https://doi.org/10.1186/s12915-020-0773-x (*co-first authors)

 

Gruber, C.*, Patel, R. S.*, Trachman, R., Lepow, L., Amanat, F., Krammer, F., Wilson, K. M., Onel, K., Geanon, D., Tuballes, K., Patel, M., Mouskas, K., Simons, N., Barcessat, V., Del Valle, D., Udondem, S., Kang, G., Gangadharan, S., Ofori-Amanfo, G., Rahman, A., Kim-Schulze, S., Charney, A., Gnjatic, S., Gelb, B., Merad, M., & Bogunovic, D. (2020). Mapping systemic inflammation and antibody responses in multisystem inflammatory syndrome in children (MIS-C). Cell. https://doi.org/10.1016/j.cell.2020.09.034 (*co-first authors)

 

Patel, R. S.*, Taft, J.*, Buta, S., Martin-Fernandez, M., Kaur, K., Figueroa, D., Goff, M., Albrecht, R., Lim, J., Zhangi, L., Garcia-Sastre, A., Rosenberg, B. R., & Bogunovic, D. (2020). Broad-spectrum RNA antiviral inspired by ISG15 deficiency. Manuscript in submission at Cell. (*co-first authors)

​

Malle, L., Patel, R. S., Martin-Fernandez, M., Stewart, O. J., Philippot, Q., Buta, S., ... & Rosenberg, B. R. (2023). Autoimmunity in Down’s syndrome via cytokines, CD4 T cells and CD11c+ B cells. Nature, 1-10.

 

Prescott, R. A., Pankow, A. P., de Vries, M., Crosse, K., Patel, R. S., Alu, M., ... & Günther, T. (2023). A comparative study of in vitro air-liquid interface culture models of the human airway epithelium evaluating cellular heterogeneity and gene expression at single cell resolution. bioRxiv, 2023.02.27.530299.

 

Danziger, O., Patel, R. S., DeGrace, E. J., Rosen, M. R., & Rosenberg, B. R. (2022). Inducible CRISPR activation screen for interferon-stimulated genes identifies OAS1 as a SARS-CoV-2 restriction factor. PLoS Pathogens, 18(4), e1010464.

 

Jurczyszak, D., Manganaro, L., Buta, S., Gruber, C., Martin-Fernandez, M., Taft, J., Patel R.S.,.. & Rosenberg, B. R. (2022). ISG15 deficiency restricts HIV-1 infection. PLoS Pathogens, 18(3), e1010405.

Patel, R. S., Tomlinson, J. E., Divers, T. J., Van de Walle, G. R., & Rosenberg, B. R. (2021). Single-cell resolution landscape of equine peripheral blood mononuclear cells reveals diverse cell types including T-bet+ B cells. BMC biology, 19, 1-18.

 

Cohen, P., DeGrace, E. J., Danziger, O., Patel, R. S., & Rosenberg, B. R. (2021). Unambiguous detection of SARS-CoV-2 subgenomic mRNAs with single cell RNA sequencing. bioRxiv.

 

Nilsson-Payant, B. E., Uhl, S., Grimont, A., Doane, A. S., Cohen, P., Patel, R. S., ... & Whelan, S. P. (2021). The NF-κB transcriptional footprint is essential for SARS-CoV-2 replication. Journal of Virology, 95(23), e01257-21.

 

Malle, L., Bastard, P., Martin-Nalda, A., Carpenter, T., Bush, D., Patel, R.S., ... & Casanova, J. L. (2021). Atypical inflammatory syndrome triggered by SARS-CoV-2 in infants with Down syndrome. Journal of Clinical Immunology, 41(7), 1457-1462.

 

Tomlinson, J. E., Wolfisberg, R., Fahnøe, U., Patel, R. S., Trivedi, S., Kumar, A., ... & Van de Walle, G. R. (2021). Pathogenesis, MicroRNA‐122 gene‐regulation, and protective immune responses after acute equine hepacivirus infection. Hepatology, 74(3), 1148-1163.

 

Taft, J., Markson, M., Legarda, D., Patel, R.S., Chan, M., Malle, L., ... & Richardson, A. (2021). Human TBK1 deficiency leads to autoinflammation driven by TNF-induced cell death. Cell, 184(17), 4447-4463. e20.

 

Kaji, D. A., Montero, A. M., Patel, R.S., & Huang, A. H. (2021). Transcriptional profiling of mESC-derived tendon and fibrocartilage cell fate switch. Nature Communications, 12(1), 4208.

 

Tanaka, S., Nelson, G., Olson, C. A., Buzko, O., Higashide, W., Shin, A., Patel, R. S., ... & Gonzales, M. (2021). An ACE2 Triple Decoy that neutralizes SARS-CoV-2 shows enhanced affinity for virus variants. Scientific Reports, 11(1), 12740.

 

Sieling, P., King, T., Wong, R., Nguyen, A., Wnuk, K., Gabitzsch, E. R., Patel, R. S., ... & Rice, A. (2021). Prime hAd5 spike+ nucleocapsid vaccination induces ten-fold increases in mean T-cell responses in phase 1 subjects that are sustained against spike variants. medRxiv, 2021.04.05.21254940.

 

Rice, A., Verma, M., Shin, A., Zakin, L., Sieling, P., Tanaka, S., Patel, R. S.,... & Dinkins, K. (2021). The Dual-Antigen Ad5 COVID-19 Vaccine Delivered as an Intranasal Plus Subcutaneous Prime Elicits Th1 Dominant T-Cell and Humoral Responses in CD-1 Mice. bioRxiv, 2021.03.22.436476.

 

Tanaka, S., Olson, A., Nelson, G., Buzko, O., Higashide, W., Shin, A., Patel, R. S.,... & Gonzales, M. (2021). A recombinant ‘ACE2 Triple Decoy’ that traps and neutralizes SARS-CoV-2 shows enhanced affinity for highly transmissible SARS-CoV-2 variants. BioRxiv, 2021.03.09.434641.

 

Harman, R. M., Patel, R. S., Fan, J. C., Park, J. E., Rosenberg, B. R., & Van de Walle, G. R. (2021). Single-cell RNA sequencing of equine mesenchymal stromal cells from primary donor-matched tissue sources reveals functional heterogeneity in immune modulation and cell motility. Stem Cell Research & Therapy, 11, 1-15.

 

Mulhern, J., Fadia, A., Patel, R. S., Ficociello, L., Willetts, J., Dahne-Steuber, I., ... & Lin, A. (2021). Fewer ESKD dialysis patients (PTS) reach antibody (AB) levels consistent with neutralizing titers when vaccinated with AD26. COV2. S compared with mRNA COVID-19 vaccines. Journal of the American Society of Nephrology, 97-97.

 

Tanaka, S., Olson, A., Nelson, G., Buzko, O., Higashide, W., Shin, A., Patel, R. S.,... & Gonzales, M. (2021). A SARS-CoV-2-neutralizing ACE2 decoy shows high affinity for N501Y and L452R variants. Topics in Antiviral Medicine, 137-137.